Metabolism/excretion: It can be metabolized to norhydrocodone by cytochrome P450 3A4 and to hydromorphone, also biologically active, by cytochrome P450 2D6.Concurrent utilization of hydrocodone with CYP3A4 inhibitors or discontinuation of CYP3A4 inducers may result in a fatal overdose of hydrocodone. Consequently, it can be crucial to prevent this